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All Folic Acid study protocols

Folic Acid, Vitamin D, Iron and Vitamin C: study protocols

13 study groups took Folic Acid together with Vitamin D, Iron and Vitamin C. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

13 study groups in 10 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 85% of 13 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
11
500 mcg to 1 mg
2

Dose per serving from research: Vitamin D

7 study groups in 4 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 IU to 250 IU, 57% of 7 study groups.

Daily doseStudy groups
100 IU or less
1
100 IU to 250 IU
4
250 IU to 500 IU
2

Dose per serving from research: Iron

12 study groups in 9 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 75% of 12 study groups.

Daily doseStudy groups
10 mg or less
1
10 mg to 25 mg
0
25 mg to 50 mg
9
50 mg to 100 mg
2

Dose per serving from research: Vitamin C

12 study groups in 9 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 75% of 12 study groups.

Daily doseStudy groups
25 mg or less
1
25 mg to 50 mg
0
50 mg to 100 mg
9
100 mg to 250 mg
2

Commonly used together

13 of 13 study groups took Folic Acid, Vitamin D, Iron and Vitamin C with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.

What was given together, not what works together.

Taken withStudy groups
Vitamin A
13
Vitamin E
13
Copper
12
Zinc
12
Iodine
11
Niacin
11
Selenium
11
Vitamin B12
10
Vitamin B6
9
Riboflavin
8

13 study groups

Study
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
2008 · Multiple micronutrients · Pregnant women resident in disadvantaged rural counties in Shaanxi Province, China; eligible women enrolled before 28 weeks’ gestation
400 mcg5 mcg30 mg70 mg—1,899
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg200 IU30 mg70 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg200 IU30 mg70 mg——
Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial
2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation
400 mcg5 mcg30 mg70 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg10 mcg—100 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg85.7 IU8.57 mg10 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg200 IU30 mg70 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg200 IU30 mg70 mg180 days515
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg5 mcg27 mg85 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg5 mcg27 mg85 mg—176