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Folic Acid, Vitamin B6, Vitamin D and Iron: study protocols

10 study groups took Folic Acid together with Vitamin B6, Vitamin D and Iron. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

10 study groups in 8 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 90% of 10 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
9
500 mcg to 1 mg
1

Dose per serving from research: Vitamin B6

10 study groups in 8 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 80% of 10 study groups.

Daily doseStudy groups
1 mg or less
1
1 mg to 2.5 mg
8
over 2.5 mg
1

Dose per serving from research: Vitamin D

5 study groups in 3 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 IU to 250 IU, 80% of 5 study groups.

Daily doseStudy groups
100 IU or less
1
100 IU to 250 IU
4

Dose per serving from research: Iron

9 study groups in 7 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 78% of 9 study groups.

Daily doseStudy groups
5 mg to 10 mg
1
10 mg to 25 mg
1
25 mg to 50 mg
7

Commonly used together

10 of 10 study groups took Folic Acid, Vitamin B6, Vitamin D and Iron with something else. Shown: what 3 or more different studies gave. The 10 most common of 11.

What was given together, not what works together.

Taken withStudy groups
Vitamin B12
10
Vitamin A
9
Vitamin C
9
Vitamin E
9
Zinc
9
Copper
8
Iodine
8
Niacin
8
Riboflavin
7
Selenium
7

10 study groups

Study
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg1.9 mg200 IU30 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg1.9 mg200 IU30 mg——
Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial
2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation
400 mcg1.9 mg5 mcg30 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg2.2 mg10 mcg———
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg271 mcg85.7 IU8.57 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg1.9 mg200 IU30 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg1.9 mg200 IU30 mg180 days515
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
400 mcg2.6 mg10 mcg12 mg—870
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg1.9 mg5 mcg27 mg—176
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
400 mcg1.9 mg—30 mg12 weeks105