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Folic Acid, Vitamin B6, Riboflavin, Vitamin D and Zinc: study protocols

6 study groups took Folic Acid together with Vitamin B6, Riboflavin, Vitamin D and Zinc. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

6 study groups in 5 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 100% of 6 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
6

Dose per serving from research: Vitamin B6

6 study groups in 5 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 67% of 6 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
0
1 mg to 2.5 mg
4
over 2.5 mg
1

Dose per serving from research: Riboflavin

6 study groups in 5 studies say how much Riboflavin participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 83% of 6 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
0
500 mcg to 1 mg
0
1 mg to 2.5 mg
5

Dose per serving from research: Zinc

6 study groups in 5 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 50% of 6 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
0
5 mg to 10 mg
1
10 mg to 25 mg
3
25 mg to 50 mg
1

Commonly used together

6 of 6 study groups took Folic Acid, Vitamin B6, Riboflavin, Vitamin D and Zinc with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Iron
6
Vitamin B12
6
Copper
5
Iodine
5
Niacin
5
Vitamin A
5
Vitamin C
5
Vitamin E
5
Selenium
4
Thiamine
3

6 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg2.2 mg1.8 mg10 mcg30 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg271 mcg200 mcg85.7 IU2.14 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg1.9 mg1.4 mg200 IU15 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg1.9 mg1.4 mg200 IU15 mg180 days515
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
400 mcg2.6 mg1.8 mg10 mcg10 mg—870
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
400 mcg1.9 mg1.4 mg—15 mg12 weeks105