Folic Acid, Vitamin B12, Riboflavin and Copper: study protocols
6 study groups took Folic Acid together with Vitamin B12, Riboflavin and Copper. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Folic Acid
6 study groups in 5 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 83% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 1 |
| 250 mcg to 500 mcg | 5 |
Dose per serving from research: Vitamin B12
6 study groups in 5 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 67% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 0.5 mcg or less | 1 |
| 0.5 mcg to 1 mcg | 1 |
| 1 mcg to 2.5 mcg | 0 |
| 2.5 mcg to 5 mcg | 4 |
Dose per serving from research: Riboflavin
6 study groups in 5 studies say how much Riboflavin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 67% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg or less | 1 |
| 250 mcg to 500 mcg | 1 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 4 |
Dose per serving from research: Copper
6 study groups in 5 studies say how much Copper participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 67% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg to 500 mcg | 1 |
| 500 mcg to 1 mg | 1 |
| 1 mg to 2.5 mg | 4 |
Commonly used together
6 of 6 study groups took Folic Acid, Vitamin B12, Riboflavin and Copper with something else. Shown: what 3 or more different studies gave. The 10 most common of 11.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Iron | 6 |
| Niacin | 6 |
| Vitamin A | 6 |
| Vitamin B6 | 6 |
| Vitamin E | 6 |
| Zinc | 6 |
| Iodine | 5 |
| Selenium | 5 |
| Vitamin C | 5 |
| Vitamin D | 5 |
6 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 400 mcg | 2.6 mcg | 1.8 mg | 2 mg | — | — |
| Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam 2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant | 400 mcg | 0.371 mcg | 200 mcg | 286 mcg | 54 weeks | 1,469 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 2.6 mcg | 1.4 mg | 2 mg | 180 days | 516 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 2.6 mcg | 1.4 mg | 2 mg | 180 days | 515 |
| Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial 2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies | 150 mcg | 0.9 mcg | 500 mcg | 560 mcg | 36 weeks | 130 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 400 mcg | 2.6 mcg | 1.4 mg | 2 mg | 12 weeks | 105 |