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Folic Acid, Vitamin B12, Iodine, Vitamin C and Zinc: study protocols

9 study groups took Folic Acid together with Vitamin B12, Iodine, Vitamin C and Zinc. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

9 study groups in 7 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 67% of 9 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
0
250 mcg to 500 mcg
6
500 mcg to 1 mg
2

Dose per serving from research: Vitamin B12

9 study groups in 7 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 78% of 9 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
7

Dose per serving from research: Iodine

9 study groups in 7 studies say how much Iodine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mcg to 250 mcg, 89% of 9 study groups.

Daily doseStudy groups
50 mcg or less
1
50 mcg to 100 mcg
0
100 mcg to 250 mcg
8

Dose per serving from research: Vitamin C

8 study groups in 6 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 75% of 8 study groups.

Daily doseStudy groups
10 mg or less
1
10 mg to 25 mg
0
25 mg to 50 mg
1
50 mg to 100 mg
6

Dose per serving from research: Zinc

9 study groups in 7 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 78% of 9 study groups.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
1
10 mg to 25 mg
7

Commonly used together

9 of 9 study groups took Folic Acid, Vitamin B12, Iodine, Vitamin C and Zinc with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Copper
9
Selenium
9
Vitamin A
9
Vitamin D
9
Vitamin E
9
Iron
8
Vitamin B6
8
Niacin
7
Riboflavin
4

9 study groups

Study
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg2.6 mcg150 mcg70 mg15 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg2.6 mcg150 mcg70 mg15 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg0.371 mcg21.4 mcg10 mg2.14 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg2.6 mcg150 mcg70 mg15 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg2.6 mcg150 mcg70 mg15 mg180 days515
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg2.6 mcg220 mcg85 mg12 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg2.6 mcg220 mcg85 mg12 mg—176
Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial
2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years
40 mcg2.4 mcg180 mcg50 mg10 mg26 weeks104
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
400 mcg2.6 mcg150 mcg—15 mg12 weeks105