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Folic Acid, Vitamin A, Vitamin C, Zinc and Iron: study protocols

11 study groups took Folic Acid together with Vitamin A, Vitamin C, Zinc and Iron. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

11 study groups in 9 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 73% of 11 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
2
250 mcg to 500 mcg
8
over 500 mcg
1

Dose per serving from research: Vitamin A

10 study groups in 8 studies say how much Vitamin A participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 70% of 10 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
1
250 mcg to 500 mcg
2
500 mcg to 1 mg
7

Dose per serving from research: Vitamin C

10 study groups in 8 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 70% of 10 study groups.

Daily doseStudy groups
10 mg or less
1
10 mg to 25 mg
0
25 mg to 50 mg
2
50 mg to 100 mg
7

Dose per serving from research: Zinc

11 study groups in 9 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 64% of 11 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
2
5 mg to 10 mg
0
10 mg to 25 mg
7
over 25 mg
1

Dose per serving from research: Iron

10 study groups in 8 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 80% of 10 study groups.

Daily doseStudy groups
10 mg or less
1
10 mg to 25 mg
1
25 mg to 50 mg
8

Commonly used together

10 of 11 study groups took Folic Acid, Vitamin A, Vitamin C, Zinc and Iron with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Copper
9
Vitamin D
9
Vitamin E
9
Iodine
8
Niacin
8
Selenium
8
Vitamin B12
8
Vitamin B6
7
Riboflavin
5
Thiamine
3

11 study groups

Study
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
2008 · Multiple micronutrients · Pregnant women resident in disadvantaged rural counties in Shaanxi Province, China; eligible women enrolled before 28 weeks’ gestation
400 mcg800 mcg70 mg15 mg30 mg—1,899
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg800 mcg70 mg15 mg30 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg800 mcg70 mg15 mg30 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg1 mg100 mg30 mg———
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg114 mcg10 mg2.14 mg8.57 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg800 mcg70 mg15 mg30 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg800 mcg70 mg15 mg30 mg180 days515
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg770 mcg85 mg12 mg27 mg165 days749
Short-term daily or weekly administration of micronutrient Sprinkles has high compliance and does not cause iron overload in Chinese schoolchildren: a cluster-randomised trial
2006 · daily group · Children aged 3–6 years in a kindergarten in northern China
150 mcg300 mcg50 mg5 mg30 mg13 weeks—
Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti
2007 · Sprinkles-WSB (S-WSB) · Children aged 9–24 months in rural Haiti receiving take-home fortified wheat-soy blend rations
160 mcg400 mcg30 mg5 mg12.5 mg60 days254