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Folic Acid, Iron, Iodine, Vitamin B12 and Zinc: study protocols

10 study groups took Folic Acid together with Iron, Iodine, Vitamin B12 and Zinc. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

10 study groups in 8 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 70% of 10 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
7
500 mcg to 1 mg
2

Dose per serving from research: Iron

10 study groups in 8 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 70% of 10 study groups.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
1
25 mg to 50 mg
7

Dose per serving from research: Iodine

10 study groups in 8 studies say how much Iodine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mcg to 250 mcg, 80% of 10 study groups.

Daily doseStudy groups
50 mcg or less
1
50 mcg to 100 mcg
1
100 mcg to 250 mcg
8

Dose per serving from research: Vitamin B12

10 study groups in 8 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 70% of 10 study groups.

Daily doseStudy groups
0.5 mcg or less
1
0.5 mcg to 1 mcg
1
1 mcg to 2.5 mcg
0
2.5 mcg to 5 mcg
7
over 5 mcg
1

Dose per serving from research: Zinc

10 study groups in 8 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 70% of 10 study groups.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
2
10 mg to 25 mg
7

Commonly used together

10 of 10 study groups took Folic Acid, Iron, Iodine, Vitamin B12 and Zinc with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Copper
9
Selenium
9
Vitamin A
9
Vitamin B6
9
Vitamin D
9
Vitamin E
9
Vitamin C
8
Niacin
7
Riboflavin
6
Thiamine
3

10 study groups

Study
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg30 mg150 mcg2.6 mcg15 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg30 mg150 mcg2.6 mcg15 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg8.57 mg21.4 mcg0.371 mcg2.14 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg30 mg150 mcg2.6 mcg15 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg30 mg150 mcg2.6 mcg15 mg180 days515
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
400 mcg12 mg150 mcg5.2 mcg10 mg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg27 mg220 mcg2.6 mcg12 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg27 mg220 mcg2.6 mcg12 mg—176
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
150 mcg6 mg90 mcg0.9 mcg10 mg36 weeks130
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
400 mcg30 mg150 mcg2.6 mcg15 mg12 weeks105