Folic Acid, Iodine, Selenium, Iron and Vitamin B12: study protocols
9 study groups took Folic Acid together with Iodine, Selenium, Iron and Vitamin B12. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Folic Acid
9 study groups in 7 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 67% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 1 |
| 250 mcg to 500 mcg | 6 |
| 500 mcg to 1 mg | 2 |
Dose per serving from research: Iodine
9 study groups in 7 studies say how much Iodine participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mcg to 250 mcg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mcg or less | 1 |
| 25 mcg to 50 mcg | 0 |
| 50 mcg to 100 mcg | 1 |
| 100 mcg to 250 mcg | 7 |
Dose per serving from research: Selenium
9 study groups in 7 studies say how much Selenium participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mcg to 100 mcg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mcg or less | 1 |
| 10 mcg to 25 mcg | 1 |
| 25 mcg to 50 mcg | 0 |
| 50 mcg to 100 mcg | 7 |
Dose per serving from research: Iron
9 study groups in 7 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 2 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 7 |
Dose per serving from research: Vitamin B12
9 study groups in 7 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 0.5 mcg or less | 1 |
| 0.5 mcg to 1 mcg | 1 |
| 1 mcg to 2.5 mcg | 0 |
| 2.5 mcg to 5 mcg | 7 |
Commonly used together
9 of 9 study groups took Folic Acid, Iodine, Selenium, Iron and Vitamin B12 with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Copper | 9 |
| Vitamin A | 9 |
| Vitamin E | 9 |
| Zinc | 9 |
| Vitamin B6 | 8 |
| Vitamin C | 8 |
| Vitamin D | 8 |
| Niacin | 7 |
| Riboflavin | 5 |
| Thiamine | 3 |
9 study groups
| Study | |||||||
|---|---|---|---|---|---|---|---|
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 150 mcg | 65 mcg | 30 mg | 2.6 mcg | — | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 150 mcg | 65 mcg | 30 mg | 2.6 mcg | — | — |
| Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam 2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant | 400 mcg | 21.4 mcg | 9.29 mcg | 8.57 mg | 0.371 mcg | 54 weeks | 1,469 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 150 mcg | 65 mcg | 30 mg | 2.6 mcg | 180 days | 516 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 150 mcg | 65 mcg | 30 mg | 2.6 mcg | 180 days | 515 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 600 mcg | 220 mcg | 60 mcg | 27 mg | 2.6 mcg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 600 mcg | 220 mcg | 60 mcg | 27 mg | 2.6 mcg | — | 176 |
| Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial 2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies | 150 mcg | 90 mcg | 17 mcg | 6 mg | 0.9 mcg | 36 weeks | 130 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 400 mcg | 150 mcg | 65 mcg | 30 mg | 2.6 mcg | 12 weeks | 105 |