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Docosahexaenoic Acid and Arachidonic Acid: study protocols

9 study groups took Docosahexaenoic Acid together with Arachidonic Acid. These are the doses the studies gave. They are not a recommendation.

Docosahexaenoic Acid: what the research found →

Dose per serving from research: Docosahexaenoic Acid

7 study groups in 7 studies say how much Docosahexaenoic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg/kg to 50 mg/kg, 100% of 7 study groups.

Daily doseStudy groups
25 mg/kg to 50 mg/kg
7

Dose per serving from research: Arachidonic Acid

7 study groups in 7 studies say how much Arachidonic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg/kg to 100 mg/kg, 100% of 7 study groups.

Daily doseStudy groups
50 mg/kg to 100 mg/kg
7

Commonly used together

2 of 9 study groups took Docosahexaenoic Acid and Arachidonic Acid with something else, but nothing that 3 or more different studies gave.

9 study groups

Study
Effect of Enteral Lipid Supplement on Severe Retinopathy of Prematurity: A Randomized Clinical Trial
2021 · AA:DHA group · Extremely preterm infants born before 28 weeks’ gestational age
50 mg/kg100 mg/kg92 days101
Platelet characteristics in extremely preterm infants after fatty acid supplementation: a randomized controlled trial
2025 · AA/DHA supplement · Extremely preterm infants born before 28 weeks’ gestational age
50 mg/kg100 mg/kg—84
Enteral supplementation with arachidonic and docosahexaenoic acid and pulmonary outcome in extremely preterm infants
2024 · AA and DHA supplementation · Extremely preterm infants
50 mg/kg100 mg/kg——
Evaluation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) in a randomised controlled trial aiming for prevention of severe ROP: a substudy of the Mega Donna Mega trial
2022 · AA:DHA · Infants born before 28 weeks of gestational age
50 mg/kg100 mg/kg—84
Effect of arachidonic and docosahexaenoic acid supplementation on respiratory outcomes and neonatal morbidities in preterm infants
2023 · intervention · Very preterm infants with gestational age less than 29 weeks
50 mg/kg100 mg/kg——
Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults
2023 · LCPUFAs + LZ group, Trial 2 · Healthy Japanese adults aged 55–79 with memory complaints and no dementia; cognitive-decline subgroup had MoCA-J scores below 23
300 mg120 mg12 weeks96
Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults
2023 · LCPUFAs + LZ group, Trial 1 · Healthy Japanese adults aged 55–79 with memory complaints and no dementia; cognitive-decline subgroup had MoCA-J scores below 23
300 mg120 mg24 weeks40
Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid: A secondary analysis of the Mega Donna Mega trial
2023 · AA:DHA supplementation group · Extremely preterm infants born before 28 weeks’ gestation
50 mg/kg100 mg/kg——
Proteomic Profile in Retinopathy of Prematurity: A Secondary Analysis of the Mega Donna Mega Randomized Clinical Trial
2026 · AA/DHA supplementation · Extremely preterm infants born before 28 weeks’ gestational age
50 mg/kg100 mg/kg—84