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Collagen and Hyaluronic Acid: study protocols

6 study groups took Collagen together with Hyaluronic Acid. These are the doses the studies gave. They are not a recommendation.

Collagen: what the research found →

Dose per serving from research: Collagen

6 study groups in 6 studies say how much Collagen participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 g to 2.5 g, 33% of 6 study groups.

Daily doseStudy groups
100 mg or less
1
100 mg to 250 mg
0
250 mg to 500 mg
1
500 mg to 1 g
1
1 g to 2.5 g
2
2.5 g to 5 g
1

Dose per serving from research: Hyaluronic Acid

5 study groups in 5 studies say how much Hyaluronic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 60% of 5 study groups.

Daily doseStudy groups
25 mg to 50 mg
1
50 mg to 100 mg
3
100 mg to 250 mg
1

Commonly used together

6 of 6 study groups took Collagen and Hyaluronic Acid with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin C
5
Type-II Collagen
4

6 study groups

Study
The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial
2024 · CPHA group · Healthy Caucasian women aged 40–65 years with skin ageing
5 g30 mg16 weeks30
Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study
2025 · Verum · Adults with mild-to-moderate knee osteoarthritis and slight-to-moderate knee pain; mean age 62.7 years; women and men
100 mg—12 weeks36
A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study
2024 · supplement group · Adults with symptomatic MRI-confirmed lumbar osteochondrosis; age range and sex not specified
600 mg60 mg90 days26
Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
2025 · Collagen · Adults aged 35–65 with unilateral Kellgren-Lawrence grade 2–3 knee osteoarthritis
2 g100 mg8 weeks16
Skin Anti-Aging Efficacy of Enzyme-Treated Supercritical Caviar Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
2023 · combination group · Adults aged 30–60 years with crow’s feet wrinkle grade 3 or higher and low cheek moisture; all sexes.
500 mg240 mg8 weeks15
The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study
2025 · collagen group · men and women aged 35–65 with grade 1 or 2 meniscal tears
2 g100 mg8 weeks17
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