Alpha-Lipoic Acid and Vitamin E: study protocols
11 study groups took Alpha-Lipoic Acid together with Vitamin E. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Alpha-Lipoic Acid
11 study groups in 9 studies say how much Alpha-Lipoic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 64% of 11 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 0 |
| 500 mg to 1 g | 7 |
| 1 g to 2.5 g | 1 |
Dose per serving from research: Vitamin E
6 study groups in 5 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg and 500 mg to 1 g, 33% of 6 study groups each.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 0 |
| 100 mg to 250 mg | 2 |
| 250 mg to 500 mg | 1 |
| 500 mg to 1 g | 2 |
Commonly used together
7 of 11 study groups took Alpha-Lipoic Acid and Vitamin E with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin C | 4 |
11 study groups
| Study | ||||
|---|---|---|---|---|
| Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption 2012 · Antioxidant cocktail · Healthy young adults (mean age 25 ± 1 years) and older adults (mean age 71 ± 1 years), free of overt cardiovascular disease | 600 mg | — | 1 day | 87 |
| Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance 2014 · Antioxidant cocktail (AOC) · Adults: 30 patients with COPD and 30 age- and sex-matched controls | 600 mg | — | 1 day | 60 |
| Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy 2024 · 10-element combination tablet · Overweight or obese adults with type 2 diabetes and mild-to-moderate painful diabetic neuropathy; mean age 63 years | 600 mg | 15 mg | 26 weeks | 36 |
| Complementary therapy in diabetic patients with chronic complications: a pilot study 2010 · QALAPL group · Patients with diabetes; age and sex not reported | 100 mg | 200 mg | 90 days | 20 |
| The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial 2019 · ALA · Obese patients with non-alcoholic fatty liver disease; age and sex not specified | 1.2 g | 400 mg | 12 weeks | 23 |
| Complementary therapy in diabetic patients with chronic complications: a pilot study 2010 · QALA group · Patients with diabetes; age and sex not reported | 100 mg | 200 mg | 90 days | 20 |
| The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial 2011 · 800 mg α-tocopherol + 600 mg LA · Patients with type 2 diabetes mellitus; age and sex not reported | 600 mg | 800 mg | 120 days | 25 |
| Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress 1999 · LA alone for 2 months, followed by LA and AT combination for 2 months · Healthy adults; age and sex not specified | 600 mg | 400 IU | 120 days | 16 |
| Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress 1999 · AT alone for 2 months, followed by LA and AT combination for 2 months · Healthy adults; age and sex not specified | 600 mg | 400 IU | 120 days | 15 |
| Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures 2012 · E/C/ALA · Adults aged 50–85 with probable Alzheimer disease and MMSE scores of 16 or more | 900 mg | 800 IU | 16 weeks | — |
| Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation 2004 · antioxidant mixture · Healthy adult men and women who were active or passive smokers | 95 mg | 794 mg | 60 days | — |